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Immune cells from the gut drive development of Parkinson’s disease in the brain

Henry James
By Henry James

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Nature, Published online: 04 February 2026; doi:10.1038/d41586-026-00284-7

In ‘body-first’ Parkinson’s disease, misfolded proteins propagate from the gut’s nervous system to the brain. Immune-cell activity seems to play a key part in this spread.



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Henry James
Henry James

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